Gene linked to rheumatic disease controls cell movement
A recent study from Marie Wahren-Herlenius’ Group at CMM reveals how the gene DIORA1, associated with several rheumatic diseases, affects how cells move. The findings provide new insights into disease mechanisms and potential future therapies. The study is published in the scientific journal PNAS and the first author is PhD student Tilen Tršelič.
Publication:“Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility“, Tilen Tršelič, Nathalie Pelo, Gregoire Martin de Fremont, Vaishnavi S. Iyer, Elina Richardsdotter Andersson, Vijole Ottosson, David Alexander Frei, Elisa Baas, William A. Nyberg, Guðný Ella Thorlacius, Lara Mentlein, Sanjaykumar V. Boddul, Ioana Sandu, Diego Velasquez Pulgarin, Ákos Végvári, Carmen Gerlach, Fredrik Wermeling, Maria Sunnerhagen, Björn Wallner, Alexander Espinosa, Marie Wahren-Herlenius, PNAS, 29 September 2025, doi: 10.1073/pnas.2426917122