Jon Lampa Team

Our team investigate rheumatic pain as a distinct and complex phenomenon that cannot be fully explained by joint inflammation alone. Despite major advances in antirheumatic and biologic therapies, around one fifth of patients continue to experience persistent, difficult‑to‑treat pain, which significantly reduces quality of life. Our research aim to uncover:

• What causes persistent pain in diseases such as rheumatoid arthritis (RA)
• Which biological mechanisms maintain pain even after inflammation is treated
• How chronic pain can be predicted, prevented, and better managed

This work is grounded in the analysis of blood, cerebrospinal fluid, and functional MRI, allowing the team to map pain‑related pathways in both the immune system and the central nervous system. Immune mediators that amplify pain signaling. Moreover, we investigate immune mediators that amplify pain signaling and the interplay between fatigue, pain, and disease activity.

Chronic pain and fatigue remain among the most disabling symptoms for people with autoimmune diseases. Even when inflammation is well treated, pain can continue to impair work ability, daily functioning, and quality of life.

Our research addresses this gap by:

• Improving understanding of pain mechanisms
• Supporting development of more effective pain treatments
• Reducing long‑term disability and healthcare burden
• Enhancing patient‑centered outcomes in rheumatology

The TRAVAGA study is a placebo‑controlled clinical trial investigating whether non‑invasive auricular vagus nerve stimulation (taVNS) can reduce chronic inflammation and pain in people with difficult‑to‑treat rheumatoid arthritis (RA). It is conducted in collaboration with Karolinska Institutet and six rheumatology clinics in Sweden. ClinicalTrials.gov ID: NCT06779123

Principal Investigator: Jon Lampa, jon.lampa@ki.se

Contact: Jacopo Fontana, Study coordinator Jacopo.fontana.2@ki.se

Jon Lampa, MD, Senior consultant rheumatologist, Adjunct Professor, jon.lampa@ki.se

Team members at CMM:

Caroline Wasén, PhD, Postdoc, Caroline.Wasen@ki.se

Kristin Waldenlind, MD, PhD, Postdoc, Kristin.Waldenlind@ki.se

Jacopo Fontana, PhD, Postdoc, jacopo.fontana.2@ki.se

Vilija Oke, MD, PhD, Associate professor, Vilija.Oke@ki.se

Mirjam de Vries, MD, PhD, Postdoc, Mirjam.devries@regionstockholm.se

Kristina Lend, PhD student, assistant coordinator Kristina.Lend@ki.se

Reem Altawil (2016) Item – Pain, mechanisms of fatigue and autonomic function in rheumatoid arthritis – Karolinska Institutet – Figshare

Priya Revathikumar (2017) Item – Role of prostaglandin E2 as a neuro-immune mediator in the cholinergic anti-inflammatory pathway – Karolinska Institutet – Figshare

Johanna Estelius (2018) Item – Neuroimmune mechanisms in chronic inflammation : translational studies of the inflammatory reflex – Karolinska Institutet – Figshare

Joakim Lindqvist (2022)  Item – Pain patterns in early rheumatoid arthritis – Karolinska Institutet – Figshare

• Article: ANNALS OF THE RHEUMATIC DISEASES. 2025;84(6):937-948

  Treatment with methotrexate plus oral prednisolone versus triple therapy (methotrexate/sulfasalazine/ hydroxychloroquine) plus intra-articular glucocorticoids in early rheumatoid arthritis: a prespecified nonrandomised subgroup analysis of clinical and radiographic data at 48 weeks from the NORD-STAR trial’s conventional treatment arm

  Hetland ML; Heiberg MS; Sokka-Isler T; Rudin A; Ostergaard M; Haavardsholm E; Rutanen J; van Vollenhoven R; Grondal G; Ornbjerg LM; Boyesen P; Lampa J; Nurmohamed M; Gudbjornsson B; Uhlig T; Kononoff A; Lend K; Krabbe S; Olsen IC; Sexton J; Horslev-Petersen K
• Article: BMC RHEUMATOLOGY. 2025;9(1):45

  Transitional and CD21^– PD-1⁺ B cells are associated with remission in early rheumatoid arthritis

  McGrath S; Sundbeck B; Thorarinsdottir K; Jonsson CA; Camponeschi A; Agelii ML; Ekwall A-KH; Hetland ML; Ostergaard M; Uhlig T; Nurmohamed M; Lampa J; Nordstrom D; Horslev-Petersen K; Gudbjornsson B; Grondal G; van Vollenhoven R; Rudin A; Martensson I-L; Gjertsson I
• Article: ACR OPEN RHEUMATOLOGY. 2025;7(1):e11742

  Circulating Baseline CXCR3⁺Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis

  Scheffler JM; Drevinge C; Lindholm C; Gjertsson I; Lend K; Hetland ML; Ostergaard M; Uhlig T; Heiberg MS; Haavardsholm EA; Nurmohamed MT; Lampa J; Sokka-Isler T; Nordstrom D; Horslev-Petersen K; Gudbjornsson B; Grondal G; van Vollenhoven R; Carlsten H; Lorentzon M; Ekwall A-KH; Rudin A; Islander U
• Article: ACR OPEN RHEUMATOLOGY. 2025;7(1):e11756

  Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis

  Vasileiadis GK; Zhang Y; Fatima T; van Vollenhoven R; Lampa J; Gudbjornsson B; Haavardsholm EA; Nordstrom D; Grondal G; Horslev-Petersen K; Lend K; Heiberg MS; Hetland ML; Nurmohamed M; Uhlig T; Sokka-Isler T; Rudin A; Maglio C
• Article: RMD OPEN. 2024;10(4):e004838

  Impaired coagulation parameters in early RA are restored by effective antirheumatic therapy: a prospective pilot study

  Dijkshoorn B; Hansildaar R; Vedder D; Soutari N; Rudin A; Nordstroem D; Gudbjornsson B; Lend K; Uhlig T; Haavardsholm EA; Grondal G; Hetland ML; Heiberg MS; Ostergaard M; Horslev-Petersen K; Lampa J; van Vollenhoven RF; Antovic A; Nurmohamed MT
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2024;83(12):1657-1665

  Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial

  Lend K; Lampa J; Padyukov L; Hetland ML; Heiberg MS; Nordstroem DC; Nurmohamed MT; Rudin A; Ostergaard M; Haavardsholm EA; Horslev-Petersen K; Uhlig T; Sokka-Isler T; Gudbjornsson B; Grondal G; Frazzei G; Christiaans J; Wolbink G; Rispens T; Twisk JWR; van Vollenhoven RF
• Article: THROMBOSIS RESEARCH. 2024;243:109135

  Tocilizumab reduces hypercoagulation in COVID-19-Perspectives from the coagulation and immunomodulation Covid assessment (Coag-ImmCovA) clinical trial

  Almskog LM; Sjostrom A; Sunden-Cullberg J; Taxiarchis A; Agren A; Freyland S; Borjesson M; Wikman A; Wahlgren CM; Wanecek M; van der Linden J; Antovic J; Lampa J; Magnusson M
• Article: RMD OPEN. 2024;10(2):e004227

  Obesity is a risk factor for poor response to treatment in early rheumatoid arthritis: a NORD-STAR study

  Dubovyk V; Vasileiadis GK; Fatima T; Zhang Y; Kapetanovic MC; Kastbom A; Rizk M; Soederbergh A; Zhao SS; van Vollenhoven RF; Hetland ML; Haavardsholm EA; Nordstrom D; Nurmohamed MT; Gudbjornsson B; Lampa J; Ostergaard M; Heiberg MS; Sokka-Isler T; Grondal G; Lend K; Horslev-Petersen K; Uhlig T; Rudin A; Maglio C
• Article: ARTHRITIS RESEARCH & THERAPY. 2024;26(1):61

  Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis

  Liu J; Idborg H; Korotkova M; Lend K; van Vollenhoven R; Lampa J; Rudin A; Nordstrom D; Gudbjornsson B; Grondal G; Uhlig T; Horslev-Petersen K; Merete HL; Ostergaard M; Nurmohamed M; Jakobsson P-J
• Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2024;53(2):94-103

  Persistent pain and its predictors after starting anti-tumour necrosis factor therapy in psoriatic arthritis: what is the role of inflammation control?

  Roseman C; Wallman JK; Joud A; Schelin MEC; Einarsson JT; Lindqvist E; Lampa J; Kapetanovic MC; Olofsson T
• Article: ARTHRITIS & RHEUMATOLOGY. 2024;76(3):363-376

  Methotrexate Safety and Efficacy in Combination Therapies in Patients With Early Rheumatoid Arthritis: A Post Hoc Analysis of a Randomized Controlled Trial

  Lend K; Koopman FA; Lampa J; Jansen G; Hetland ML; Uhlig T; Nordstroem D; Nurmohamed M; Gudbjornsson B; Rudin A; Ostergaard M; Heiberg MS; Sokka-Isler T; Horslev-Petersen K; Haavardsholm EA; Grondal G; Twisk JWR; van Vollenhoven R
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675

  CD163⁺ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier

  Lund H; Hunt MA; Kurtovic Z; Sandor K; Kagy PB; Fereydouni N; Julien A; Goritz C; Vazquez-Liebanas E; Andaloussi Mae M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
• Article: RMD OPEN. 2023;9(4):e003111

  Register-based observational study of associations between inflammatory remission, formal treatment targets and the use of disease-modifying antirheumatic drugs among patients with early rheumatoid arthritis

  Lindqvist J; Askling J; Lampa J
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(10):1286-1295

  Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial

  Ostergaard M; van Vollenhoven RF; Rudin A; Hetland ML; Heiberg MS; Nordstrom DC; Nurmohamed MT; Gudbjornsson B; Ornbjerg LM; Boyesen P; Lend K; Horslev-Petersen K; Uhlig T; Sokka T; Grondal G; Krabbe S; Lindqvist J; Gjertsson I; Glinatsi D; Kapetanovic MC; Aga A-B; Faustini F; Parmanne P; Lorenzen T; Giovanni C; Back J; Hendricks O; Vedder D; Rannio T; Grenholm E; Ljosa MK; Brodin E; Lindegaard H; Soderbergh A; Rizk M; Kastbom A; Larsson P; Uhrenholt L; Just SA; Stevens DJ; Laurbjerg TB; Bakland G; Olsen IC; Haavardsholm EA; Lampa J
• Article: WELLCOME OPEN RESEARCH. 2023;8:493

  Cerebrospinal fluid immune cells appear similar across neuropathic and non-neuropathic pain conditions.

  Hore Z; Royds J; Abuukar Abdullahi R; Lampa J; Al-Kaisy A; Denk F
• Article: PLOS ONE. 2023;18(12):e0295838

  Anakinra or tocilizumab in patients admitted to hospital with severe covid-19 at high risk of deterioration (IMMCoVA): A randomized, controlled, open-label trial

  Sunden-Cullberg J; Chen P; Habel H; Skorup P; Janols H; Rasmuson J; Niward K; Balkhed AO; Chatzidionysiou K; Asgeirsson H; Blennow O; Parke A; Svensson A-K; Muvva JR; Ljunggren H-G; Horne A-C; Aden U; Henter J-I; Sonnerborg A; Vesterbacka J; Nowak P; Lampa J
• Article: LANCET RHEUMATOLOGY. 2022;4(10):E688-E698

  Sex differences in remission rates over 24 weeks among three different biological treatments compared to conventional therapy in patients with early rheumatoid arthritis (NORD-STAR): a post-hoc analysis of a randomised controlled trial

  Lend K; van Vollenhoven RF; Lampa J; Hetland ML; Haavardsholm EA; Nordstrom D; Nurmohamed M; Gudbjornsson B; Rudin A; Ostergaard M; Uhlig T; Grondal G; Horslev-Petersen K; Heiberg MS; Sokka-Isler T; Koopman FA; Twisk JWR; Van der Horst-Bruinsma I
• Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(7):1393-1402

  Blood chemokine levels are markers of disease activity but not predictors of remission in early rheumatoid arthritis

  Aldridge J; Lundell A-C; Andersson K; Mark L; Hetland ML; Ostergaard M; Uhlig T; Heiberg MS; Haavardsholm EA; Nurmohamed M; Lampa J; Nordstrom D; Horslev-Petersen K; Gudbjornsson B; Grondal G; van Vollenhoven R; Rudin A
• Article: ACR OPEN RHEUMATOLOGY. 2022;4(6):492-502

  Unmet Needs in Rheumatoid Arthritis: A Subgroup of Patients With High Levels of Pain, Fatigue, and Psychosocial Distress 3 Years After Diagnosis

  Lindqvist J; Alfredsson L; Klareskog L; Lampa J; Westerlind H
• Article: PAIN. 2022;163(3):538-547

  Distinct aberrations in cerebral pain processing differentiating patients with fibromyalgia from patients with rheumatoid arthritis

  Sandstrom A; Ellerbrock I; Lofgren M; Altawil R; Bileviciute-Ljungar I; Lampa J; Kosek E
• Article: FRONTIERS IN NEUROSCIENCE. 2022;16:942136

  Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis

  Fanton S; Altawil R; Ellerbrock I; Lampa J; Kosek E; Fransson P; Thompson WH
• Article: ARTHRITIS CARE & RESEARCH. 2021;73(9):1312-1321

  Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid Arthritis: Results From a Swedish Randomized Controlled Trial

  Olofsson T; Wallman JK; Joud A; Schelin MEC; Ernestam S; van Vollenhoven R; Saevarsdottir S; Lampa J
• Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):189

  Plasma interferon-alpha is associated with double-positivity for autoantibodies but is not a predictor of remission in early rheumatoid arthritis-a spin-off study of the NORD-STAR randomized clinical trial

  Stockfelt M; Lundell A-C; Hetland ML; Ostergaard M; Uhlig T; Heiberg MS; Haavardsholm EA; Nurmohamed MT; Lampa J; Nordstrom D; Petersen KH; Gudbjornsson B; Grondal G; Aldridge J; Andersson K; Blennow K; Zetterberg H; van Vollenhoven R; Rudin A
• Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2021;50(4):271-279

  Widespread non-joint pain in early rheumatoid arthritis

  Schelin MEC; Westerlind H; Lindqvist J; Englid E; Israelsson L; Skillgate E; Klareskog L; Alfredsson L; Lampa J
• Article: NATURE AND SCIENCE OF SLEEP. 2021;13:775-789

  Objective and Subjective Sleep in Rheumatoid Arthritis and Severe Seasonal Allergy: Preliminary Assessments of the Role of Sickness, Central and Peripheral Inflammation

  Tamm S; Lensmar C; Andreasson A; Axelsson J; Moren AF; Grunewald J; Gyllfors P; Karshikoff B; Kosek E; Lampa J; Hoglund CO; Strand V; Cervenka S; Lekander M
• Article: FRONTIERS IN MEDICINE. 2021;8:651249

  Adverse Health-Related Quality of Life Outcome Despite Adequate Clinical Response to Treatment in Systemic Lupus Erythematosus

  Gomez A; Qiu V; Cederlund A; Borg A; Lindblom J; Emamikia S; Enman Y; Lampa J; Parodis I
• Article: BMJ-BRITISH MEDICAL JOURNAL. 2020;371:m4328

  Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial

  Hetland ML; Haavardsholm EA; Rudin A; Nordstrom D; Nurmohamed M; Gudbjornsson B; Lampa J; Horslev-Petersen K; Uhlig T; Grondal G; Ostergaard M; Heiberg MS; Twisk J; Lend K; Krabbe S; Hyldstrup LH; Lindqvist J; Ekwall A-KH; Gron KL; Kapetanovic M; Faustini F; Tuompo R; Lorenzen T; Cagnotto G; Baecklund E; Hendricks O; Vedder D; Sokka-Isler T; Husmark T; Ljosa M-KA; Brodin E; Ellingsen T; Soderbergh A; Rizk M; Olsson AR; Larsson P; Uhrenholt L; Just SA; Stevens DJ; Laurberg TB; Bakland G; Olsen IC; van Vollenhoven R
• Article: ARTHRITIS CARE & RESEARCH. 2020;72(1):27-35

  Tender Joint Count and Inflammatory Activity in Patients With Established Rheumatoid Arthritis: Results From a Longitudinal Study

  Hammer HB; Michelsen B; Provan SA; Sexton J; Lampa J; Uhlig T; Kvien TK
• Article: PAIN. 2020;161(1):114-126

  Machine-learning-based knowledge discovery in rheumatoid arthritis-related registry data to identify predictors of persistent pain

  Loetsch J; Alfredsson L; Lampa J
• Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(11):2329-2338

  Effects of age, BMI and sex on the glial cell marker TSPO – a multicentre [¹¹C]PBR28 HRRT PET study

  Tuisku J; Plaven-Sigray P; Gaiser EC; Airas L; Al-Abdulrasul H; Bruck A; Carson RE; Chen M-K; Cosgrove KP; Ekblad L; Esterlis I; Farde L; Forsberg A; Halldin C; Helin S; Kosek E; Lekander M; Lindgren N; Marjamaki P; Rissanen E; Sucksdorff M; Varrone A; Collste K; Gallezot J-D; Hillmer A; Huang Y; Hoglund CO; Johansson J; Jucaite A; Lampa J; Nabulsi N; Pittman B; Sandiego CM; Stenkrona P; Rinne J; Matuskey D; Cervenka S
• Article: BRAIN BEHAVIOR AND IMMUNITY. 2019;81:272-279

  Altered cerebral pain processing of noxious stimuli from inflamed joints in rheumatoid arthritis: An event-related fMRI study

  Sandstrom A; Ellerbrock I; Jensen KB; Martinsen S; Altawil R; Hakeberg P; Fransson P; Lampa J; Kosek E
• Article: JOURNAL OF NEUROIMMUNOLOGY. 2019;334:577000

  Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [¹¹C]PBR28 positron emission tomography

  Forsberg A; Lampa J; Estelius J; Cervenka S; Farde L; Halldin C; Lekander M; Hoglund OC; Kosek E
• Article: BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY. 2019;33(3):101439

  Pain without inflammation in rheumatic diseases

  Lampa J
• Article: NEUROIMAGE. 2019;188:102-110

  Accuracy and reliability of [¹¹C]PBR28 specific binding estimated without the use of a reference region

  Plaven-Sigray P; Schain M; Zanderigo F; Farde L; Halldin C; Forsberg A; Varrone A; Jucaite A; Cervenka S; Stenkrona P; Collste K; Kander M; Kosek E; Lampa J; Hoglund CO; Rabiner EA; Gunn RN; Ogden RT; Cervenk S
• Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):60

  Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment

  Estelius J; Lengqvist J; Ossipova E; Idborg H; Le Maitre E; Andersson MLA; Brundin L; Khademi M; Svenungsson E; Jakobsson P-J; Lampa J
• Article: JOURNAL OF PROTEOMICS. 2019;190:67-76

  The human CSF pain proteome

  Khoonsari PE; Ossipova E; Lengqvist J; Svensson CI; Kosek E; Kadetoff D; Jakobsson P-J; Kultima K; Lampa J
• Article: PAIN. 2019;160(1):224-236

  Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis

  Fernandez-Zafra T; Gao T; Jurczak A; Sandor K; Hore Z; Agalave NM; Su J; Estelius J; Lampa J; Hokfelt T; Wiesenfeld-Hallin Z; Xu X; Denk F; Svensson CI
• Article: BRAIN BEHAVIOR AND IMMUNITY. 2019;75:72-83

  Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation

  Albrecht DS; Forsberg A; Sandstrom A; Bergan C; Kadetoff D; Protsenko E; Lampa J; Lee YC; Hoglund CO; Catana C; Cervenka S; Akeju O; Lekander M; Cohen G; Halldin C; Taylor N; Kim M; Hooker JM; Edwards RR; Napadow V; Kosek E; Loggia ML
• Article: ARTHRITIS CARE & RESEARCH. 2018;70(5):703-712

  Pain Catastrophizing, Subjective Outcomes, and Inflammatory Assessments Including Ultrasound: Results From a Longitudinal Study of Rheumatoid Arthritis Patients

  Hammer HB; Uhlig T; Kvien TK; Lampa J
• Article: BRAIN BEHAVIOR AND IMMUNITY. 2018;68:146-157

  Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [¹¹C]PBR28 PET study

  Tamm S; Cervenka S; Forsberg A; Estelius J; Grunewald J; Gyllfors P; Karshikoff B; Kosek E; Lampa J; Lensmar C; Strand V; Akerstedt T; Halldin C; Ingvar M; Hoglund CO; Lekander M
• Article: ARTHRITIS CARE & RESEARCH. 2018;70(2):205-212

  Dietary Intake of Polyunsaturated Fatty Acids and Pain in Spite of Inflammatory Control Among Methotrexate-Treated Early Rheumatoid Arthritis Patients

  Lourdudoss C; Di Giuseppe D; Wolk A; Westerlind H; Klareskog L; Alfredsson L; van Vollenhoven RF; Lampa J
• Article: PLOS ONE. 2018;13(2):e0193210

  Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen

  Revathikumar P; Estelius J; Karmakar U; Le Maitre E; Korotkova M; Jakobsson P-J; Lampa J
• Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2017;(121)

  Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

  Le Maitre E; Revathikumar P; Estelius J; Lampa J
• Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):256

  Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism

  Revathikumar P; Bergqvist F; Gopalakrishnan S; Korotkova M; Jakobsson P-J; Lampa J; Le Maitre E
• Article: ARTHRITIS CARE & RESEARCH. 2016;68(8):1061-1068

  Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate

  Altawil R; Saevarsdottir S; Wedren S; Alfredsson L; Klareskog L; Lampa J
• Article: BRAIN BEHAVIOR AND IMMUNITY. 2016;54:149-157

  In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects

  Kanegawa N; Collste K; Forsberg A; Schain M; Arakawa R; Jucaite A; Lekander M; Hoglund CO; Kosek E; Lampa J; Halldin C; Farde L; Varrone A; Cervenka S
• Article: FRONTIERS IN HUMAN NEUROSCIENCE. 2016;10:107

  Intrinsic Brain Connectivity in Chronic Pain: A Resting-State fMRI Study in Patients with Rheumatoid Arthritis

  Flodin P; Martinson S; Altawil R; Waldheim E; Lampa J; Kosek E; Fransson P
• Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt B):155-162

  Impaired vagus-mediated immunosuppression in microsomal prostaglandin E synthase-1 deficient mice

  Le Maitre E; Revathikumar P; Idborg H; Raouf J; Korotkova M; Jakobsson P-J; Lampa J
• Article: JOURNAL OF NEUROIMMUNOLOGY. 2015;280:49-55

  Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain – Interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis

  Kosek E; Altawil R; Kadetoff D; Finn A; Westman M; Le Maitre E; Andersson M; Jensen-Urstad M; Lampa J
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(31):12728-12733

  Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice

  Lampa J; Westman M; Kadetoff D; Agreus AN; Le Maitre E; Gillis-Haegerstrand C; Andersson M; Khademi M; Corr M; Christianson CA; Delaney A; Yaksh TL; Kosek E; Svensson CI
• Article: JOURNAL OF NEUROIMMUNOLOGY. 2012;242(1-2):33-38

  Evidence of central inflammation in fibromyalgia – Increased cerebrospinal fluid interleukin-8 levels

  Kadetoff D; Lampa J; Westman M; Andersson M; Kosek E
• Article: MUSCULOSKELETAL CARE. 2011;9(2):75-85

  Physical Activity Coaching of Patients with Rheumatoid Arthritis in Everyday Practice: A Long-term Follow-up

  Sjoquist ES; Brodin N; Lampa J; Jensen I; Opava CH
• Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2010;162(1):62-67

  Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity

  Westman M; Saha S; Morshed M; Lampa J
• Article: BRAIN BEHAVIOR AND IMMUNITY. 2010;24(5):747-758

  Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: Key role of TNFα pathway and protection by etanercept

  Aden U; Favrais G; Plaisant F; Winerdal M; Felderhoff-Mueser U; Lampa J; Lelievre V; Gressens P
• Article: DISABILITY AND REHABILITATION. 2010;32(10):816-825

  Physical-activity coaching and health status in rheumatoid arthritis: A person-oriented approach

  Sjoquist ES; Almqvist L; Asenlof P; Lampa J; Opava CH
• Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2009;70(2):136-140

  Cell Specific Synovial Expression of Nicotinic Alpha 7 Acetylcholine Receptor in Rheumatoid Arthritis and Psoriatic Arthritis

  Westman M; Engstrom M; Catrina AI; Lampa J
• Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(3):R81

  Evaluation of arthroscopy and macroscopic scoring

  Af Klint E; Catrina AI; Matt P; Neregrad P; Lampa J; Ulfgren A-K; Klareskog L; Lindblad S
• Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(3):R76

  Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis

  Hueber W; Tomooka BH; Batliwalla F; Li W; Monach PA; Tibshirani RJ; Van Vollenhoven RF; Lampa J; Saito K; Tanaka Y; Genovese MC; Klareskog L; Gregersen PK; Robinson WH
• Article: IMMUNOLOGY. 2009;126(1):140-146

  Increased proportion of CD56^bright natural killer cells in active and inactive systemic lupus erythematosus

  Schepis D; Gunnarsson I; Eloranta M-L; Lampa J; Jacobson SH; Karre K; Berg L
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2007;66(4):537-541

  High anti-collagen type-II antibody levels and induction of proinflammatory cytokines by anti-collagen antibodycontaining immune complexes in vitro characterise a distinct rheumatoid arthritis phenotype associated with acute inflammation at the time of disease onset

  Mullazehi M; Mathsson L; Lampa J; Ronnelid J
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2007;66(3):414-416

  The inflammatory reflex and risk for rheumatoid arthritis: a case-control study of human vagotomy

  Carlens C; Brandt L; Klareskog L; Lampa J; Askling J
• Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(2):448-452

  Fcγ receptor type IIIA genotype and response to tumor necrosis factor α-blocking agents in patients with rheumatoid arthritis

  Kastbom A; Bratt J; Ernestam S; Lampa J; Padyukov L; Soderkvist P; Skogh T
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2006;65(9):1237-1240

  No signs of immunoactivation in the cerebrospinal fluid during treatment with infliximab

  Andersson M; Svenungsson E; Khademi M; Lampa J; Brundin L; Wallstrom E
• Article: ARTHRITIS & RHEUMATOLOGY. 2006;54(6):1759-1771

  Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor α, interleukin-1β, and interleukin-8 from peripheral blood monocytes via Fcγ receptor IIa -: A potential pathophysiologic mechanism for humoral anti-type II collagen immunity in arthritis

  Mullazehi M; Mathsson L; Lampa J; Ronnelid J
• Article: ARTHRITIS RESEARCH & THERAPY. 2006;8(3):R64

  Immune complexes from rheumatoid arthritis synovial fluid induce FcγRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-α by peripheral blood mononuclear cells

  Mathsson L; Lampa J; Mullazehi M; Ronnelid J
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2005;64(12):1744-1749

  Longitudinal analysis of citrullinated protein/peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis:: anti-CP status predicts worse disease activity and greater radiological progression

  Rönnelid J; Wick MC; Lampa J; Lindblad S; Nordmark B; Klareskog L; van Vollenhoven RF
• Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(1):61-72

  Evidence that anti-tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints – Extended report

  Catrina AI; Trollmo C; af Klint E; Engstrom M; Lampa J; Hermansson Y; Klareskog L; Ulfgren AK
• Article: JOURNAL OF RHEUMATOLOGY. 2003;30(8):1748-1755

  Evidence for immunostimulatory effects of intramuscular gold in patients with rheumatoid arthritis:: Correlation with skin reactions

  Ernestam S; Lampa J; Rogberg S; Rönnelid J; Klareskog L; Hafström I
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2003;62(6):526-529

  Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis

  Padyukov L; Lampa J; Heimbürger M; Ernestam S; Cederholm T; Lundkvist I; Andersson P; Hermansson Y; Harju A; Klareskog L; Bratt J
• Article: RHEUMATOLOGY. 2002;41(5):484-489

  Anti-tumour necrosis factor (TNF)-α therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis

  Catrina AI; Lampa J; Ernestam S; af Klint E; Bratt J; Klareskog L; Ulfgren AK
• Article: JOURNAL OF RHEUMATOLOGY. 2002;29(1):21-28

  Effects of gold on cytokine production in vitro;: Increase of monocyte dependent interleukin 10 production and decrease of interferon-γ levels

  Lampa J; Klareskog L; Rönnelid J
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2001;60(4):423-426

  MRI guided muscle biopsy confirmed polymyositis diagnosis in a patient with interstitial lung disease

  Lampa J; Nennesmo I; Einarsdottir H; Lundberg I
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2001;60(2):133-139

  Increased peripheral T cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with soluble TNFα receptors

  Berg L; Lampa J; Rogberg S; van Vollenhoven R; Klareskog L