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Stephen Malin Team

Lipoproteins and the Immune System

About

Lipoproteins transport cholesterol and triglycerides to cells in the body. An excess of lipoproteins can result in the storage of these lipids in inappropriate tissues. This provokes the immune system and results in tissue damage, notable examples being atherosclerosis and fatty-liver disease. We want to understand how these diseases are initiated.

Our research

Lipoproteins transport cholesterol and triglycerides to and from cells in the body. An excess of APOB-lipoproteins can result in the accumulation of these lipids in inappropriate tissues. This provokes the immune system and results in tissue damage, notable examples being atherosclerosis and fatty-liver disease.

Atherosclerosis is a major cause of heart attacks and stroke, which are leading causes of death worldwide. Our approach is aimed at understanding how these diseases are initiated, where in the body this initiation occurs, and the nature of protective and pathogenic responses by the immune system. We create novel models that allow for on-demand APOB-lipoprotein accumulation and combine this with a range of the most modern and classical experimental techniques. This provides us with the opportunity to investigate basic immunology in the context of understanding mechanisms of a global health problem.

Funding

International funding:

Leducq Foundation, EU FP7 & H2020, EU-COST, Novo Nordisk

National funding:

Vetenskapsrådet Starting and Project grants
Hjärt-Lungfonden
Åke Wibergs Stiftelse
VR Linne Center CERIC

KI funding:

KID funding for PhD Students
Stiftelsen Professor Nanna Svartz fond
Dr Åke Olssons Stiftelse
Ming Wai Lau Centre for Reparative Medicine

Team leader

Stephen Malin, principal researcher, docent, stephen.malin@ki.se

Team members

Hanna Aulin, PhD student, hanna.aulin@ki.se

Giada Di Nunzio, postdoctoral researcher, giada.di.nunzio@ki.se

Aouxue Li, PhD student, aoxue.li@ki.se

Xiaoqi Li, research assistant, xiaoqi.li@ki.se

Ana Do Carmo Oliveira Coelho, postdoctoral resarcher, ana.do.carmo.oliveira.coelho@ki.se

Cong Zhang, affiliated to research, cong.zhang.2@ki.se

Xueming Zhang, external scholarship, xueming.zhang@ki.se

Selected publications

About CMM

The Center for Molecular Medicine (CMM) is a foundation instituted by the Stockholm County Council (Region Stockholm). CMM is at the heart of a close partnership with the Karolinska University Hospital and Karolinska Institutet, fueling advancements in biomedical and clinical research.

Contact

Center for Molecular Medicine Foundation, org. nr. 815201-3689

Karolinska University Hospital L8:05

Visionsgatan 18

171 76 Stockholm, Sweden

communication@cmm.se

CMM
Karolinska institutet
Karolinska universitetssjukhuset