Per Svenningsson Group
Neuropharmacology – movement disorders
About
Parkinson’s disease (PD) is a common disease where the basic pathophysiology is unclear. The next breakthrough in the treatment of PD should delay disease progression, based on insights into the underlying pathogenic process. The development of disease-modifying drugs is hampered by the lack of adequate diagnostics and biomarkers that reflect early signs of the disease.
Research
Translational Neuropharmacology
The classic motor signs of PD are often preceded by non-motor symptoms such as depression, hyposmia, REM sleep disturbance and / or constipation. It is important to develop an improved knowledge of these clinical signs of early PD as neuroprotective and reparative therapy for PD should preferably be offered at an early stage to effectively change the course of the disease. In the laboratory, cell and animal models are developed to mimic the progressive disease progression in PD. Biochemical, histological, pharmacological, molecular biology and behavioral techniques are used in these studies.
In clinical trials with patients, clinical estimates, biochemical and imaging (PET and MRI) analyzes are performed. We have started a Biopark cohort. A special emphasis is placed on non-motor symptoms in PD and the identification of biomarkers. The information is transferred to a newly developed PD quality register. The research group also studies unipolar depression in both animal models and patient samples. In addition to PD, other movement disorders are also studied, especially Huntington’s disease and ataxias.
Research project
- Receptor dynamics in neurons. Focus on adapter proteins and lipid aggregates
- Studies of progressive Parkinsonism
- Studies of depression in Parkinson’s disease and unipolar depression
- Identification of clinical biomarkers in different forms of Parkinsonism
- Pre-clinical mechanistic studies of substances with potential for testing in clinical trials in Parkinson’s disease.
For more information about our research, please visit our external website
Group leader
Per Svenningsson, professor, senior physician, per.svenningsson@ki.se
Group members
Karolinska Institutet team leaders within the Svenningsson group:
Xiaoqun Zhang, researcher – Basal Pharmacology – Behavior, Neurochemistry and Electrophysiology, xiaoqun.zhang@ki.se
Ioanna Markaki, affiliated to research, docent – Sex and Gender in Pathogenesis of Neurodegeneration with focus on Parkinson’s disease, ioanna.markaki@ki.se
Martin Paucar Arce, affiliated to research – Movement disorders, martin.paucar.arce@ki.se
All members of the group
Victor Alm, affiliated to research, victor.alm.2@ki.se
Mattias Andréasson, postdoctoral researcher, mattias.andreasson@ki.se
Ellen Appelton, affiliated to research, ellen.appleton@ki.se
Carl-Fredrik Bowin, postdoctoral researcher, carlfredrik.bowin@ki.se
Niclas Branzell, PhD student, niclas.branzell@ki.se
Valentina Brioschi, research assistant, valentina.brioschi@ki.se
Andersson Camargo, postdoctoral researcher, anderson.camargo@ki.se
Daniel Dautan, postdoctoral researcher, daniel.dautan@ki.se
Daniel Doyon, PhD student, daniel.doyon@ki.se
Lisa Hainke, research nurse, lisa.hainke@ki.se
Yachao He, affiliated to research, inga.hoffkes@ki.se
Daniel Johansson, affiliated to research, anders.johansson@ki.se
Shervin Khosousi, affiliated to research, shervin.khosousi@ki.se
Ting Liang, research assistant, ting.liang@ki.se
Sara Melin, PhD student, sara.melin@ki.se
Akshay Naraine, postdoctoral researcher, akshay.naraine@ki.se
Noemi Nicosia, affiliated to research, noemi.nicosia@ki.se
Theodora Ntetsika, PhD student, theodora.ntetsika@ki.se
Evelina Pajediene, affiliated to research, evelina.pajediene.2@ki.se
Evita Papathoma, affiliated to research, evita.papathoma@ki.se
Wojciech Paslawski, research specialist, wojciech.paslawski@ki.se
Mats AA Persson, affiliated to research, docent, mats.persson@ki.se
Vinka Potocki, research assistant, vinka.potocki@ki.se
Sven Pålhagen, affiliated to research, sven.palhagen@ki.se
Marcus Saarinen, affiliated to research, marcus.saarinen@ki.se
Katja Schach, research assistant, katja.schach@ki.se
Daulet Sharipov, affiliated to research, daulet.sharipov@ki.se
Mabel Cruz, affiliated to research, mabel.cruz@ki.se
Theodora Soumala, affiliated to research, theodora.soumala@ki.se
Andrea Sturchio, PhD student, andrea.sturchio@ki.se
Mathias Sundgren, affiliated to research, mathias.sundgren@ki.se
Peter Söderberg, system administrator, peter.soderberg@ki.se
Panagiota Tsitsi, affiliated to research, panagiota.tsitsi@ki.se
Arja Vehkala Höglund, affiliated to research, arja.vehkala.hoglund@ki.se
Sofia Vittecoq, affiliated to research, sofia.vittecoq.berglund@ki.se
Johan Wallin, PhD student, johan.wallin@ki.se
Myrthe Wassenburg, affiliated to research, myrthe.wassenburg@ki.se
Karin Wirdefeldt, adjunct professor,+46852482378, karin.wirdefeldt@ki.se
Yunting Yang, research technician, yunting.yang@ki.se
Justyna Zareba-Paslawska, research specialist, justyna.zareba-paslawska@ki.se
Selected publications
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Article: NATURE COMMUNICATIONS. 2023;14(1):5804
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Article: TRANSLATIONAL NEURODEGENERATION. 2023;12(1):42
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Article: BIOLOGICAL PSYCHIATRY. 2021;90(1):16-27
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Article: MOLECULAR PSYCHIATRY. 2021;26(7):3253-3265
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Article: MOVEMENT DISORDERS. 2021;36(6):1430-1434
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Article: MOVEMENT DISORDERS. 2021;36(2):508-514
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Article: MOVEMENT DISORDERS. 2020;35(6):1046-1054
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(30):15226-15235
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(10):2735-2740
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Article: BRAIN. 2015;138(Pt 4):963-973
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Article: SCIENCE. 2006;311(5757):77-80